The Department of Medical Physics and Biophysics at Medical University - Varna was established in July 1962. Initially, the Department was located in the main building of the Medical University, where it had two training laboratories, a research laboratory, three studies and a workshop for development and maintenance of training experimental equipment. Currently it is located in the building of the Medical College of MU - Varna, where, after the reconstruction carried out in 2010, it has three renovated training rooms, a preparatory laboratory and lecturers' studies.
After the establishment of the Faculty of Pharmacy in 2009, the Department of Physics and Biophysics became a structural unit of the new Faculty. Furthermore, TRS Mathematics and Information Technology was set up within the Department.